Identification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes.
نویسندگان
چکیده
A new natural IND-type metallo-beta-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, M(r) = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.
منابع مشابه
Identification and Characterization of a New Metallo- -Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes
Identification and Characterization of a New Metallo-Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes Mariagrazia Perilli, Bibiana Caporale, Giuseppe Celenza, Cristina Pellegrini, Jean Denis Docquier, Marilina Mezzatesta, Gian Maria Rossolini, Stefania Stefani, and Gianfranco Amicosante* Dipartimento di Scienze e Tecnologie Biomediche, Università di L’Aquila, I-67100 L’...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 8 شماره
صفحات -
تاریخ انتشار 2007